高强度聚焦超声波有多安全? 对于产科和妇科疾病的一个有趣的解决方案:系统性审查
Mostafa Maged Ali1, Chileshe Raphael Mpehle2, Esther Olusola2
1Egyptian Ministry of Health and Population, Fayoum General Hospital, Department of Obstetrics and Gynecology, Fayoum, Egypt.
Turkish journal of obstetrics and gynecology
|September 4, 2024
概括
高强度聚焦超声波 (HIFU) 是一种安全的,非侵入性的治疗妇科和产科条件. 这一元分析证实了它在大量患者队列中具有最小的不良事件的安全性.
科学领域:
- 产科和妇科 产科和妇科
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 高强度聚焦超声波 (HIFU) 提供了使用聚焦热能进行组织切除的非手术,非侵入性方法.
- 它在产科和妇科疾病中的应用需要对安全性和潜在的不良影响进行全面评估.
研究的目的:
- 系统地审查和元分析高强度聚焦超声波 (HIFU) 对各种产科和妇科疾病的安全结果.
- 在这个患者群体中评估与HIFU治疗相关的不良事件的发生率和严重程度.
主要方法:
- 在PubMed,Scopus和Science Direct数据库中进行了系统的文献搜索,直到2024年1月20日.
- 对来自56项研究的数据进行了单臂元分析,其中包括11,740名患者,将二分结果作为风险比率 (RR) 和连续结果作为平均变化进行了聚合.
- 根据干预性放射学学会 (SIR) 标准对不良事件进行分类.
主要成果:
- 观察到较低的轻微不良事件发生率,包括治疗部位疼痛 (RR:0.61),异常的阴道泄漏 (RR:0.16) 和轻度发烧 (RR:0.005).
- 下肢的感觉异常是罕见的 (19/3390) 并且在一个月内消失.
- 罕见的SIR B型不良事件,如表面烧伤 (RR:0.012) 和疼痛 (大腿/周:0.1,腹部下部:0.38). 只有32/3017名患者发生了阴道出血. 没有报告重大不良事件或死亡.
结论:
- 高强度聚焦超声波 (HIFU) 显示出有利的安全性概况,用于治疗产科和妇科疾病,单独或与其他药物结合使用.
- 与传统方法相比,该疗法显示出有希望的疗效,显著不良事件的风险非常低.
- 这一全面的元分析提供了强有力的证据,支持HIFU在这个临床领域的安全性.
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