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黑色素通过调节NADPH氧化酶4-诱导的铁和减轻线粒体功能障碍来缓解骨关节炎

Qi Wang1, Beijie Qi1, Shi Shi1

  • 1Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, China.

Journal of pineal research
|September 4, 2024
PubMed
概括

Melatonin 通过抑制 chondrocytes 中的 NADPH 氧化酶 4 (NOX4) 来抑制骨关节炎中的铁依赖细胞死亡,称为铁亡. 这种机制可以防止氧化应激和线粒体功能障碍,为骨关节炎提供有前途的治疗方法.

关键词:
在NADPH氧化酶4中.软骨 软骨 软骨是一种铁性化 (ferroptosis) 是一种黑激素是什么意思 黑激素是什么意思这是线粒体的线粒体.骨关节炎是一种关节炎.有活性氧物种的反应性氧物种.

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