类捆绑网络或格子:使用类似蛋白质的化学显示来控制交叉链接和自我组装
Amanda L McCahill1, Tianren Zhang1,2, Jeffery G Saven2
1Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.
ACS nano
|September 4, 2024
概括
研究人员使用修改的捆束类制造了新的网和复杂的网格. 这些自组装结构为先进的材料应用提供可控制的性能和独特的多孔形态.
科学领域:
- 生物材料科学 生物材料科学
- 超分子化学 超分子化学
- 体工程是什么? 体工程是什么?
背景情况:
- 卷轴,称为捆绑,作为构建复杂分子架构的基石.
- 引入具有特定功能的非天然氨基酸可以精确控制组合和网络形成.
研究的目的:
- 为控制的共价交联和自我组装而设计用基基基 (alloc) 保护的捆绑类.
- 研究网的形成和复杂的网格,具有可调节的特性和多孔形态.
- 探索使用乙烯 (thiol-ene) 点击化学来创建强大的基于的材料.
主要方法:
- 选择性地将合物保护的氨酸和半氨酸纳入捆绑分子中.
- 通过溶液组合和随后的乙烯照片点击交叉链接形成网.
- 网络属性的表征,使用类重量学.
- 使用传输电子显微镜 (TEM),冷TEM和小角度X射线散射 (SAXS) 分析自组装格子结构.
- 使用粗粒度建模和机器学习确定粒子排列.
主要成果:
- 通过基功能化溶氨酸成功合成和修改捆绑分子.
- 证明可控制的网形成与可调节的交叉连接度.
- 通过疏水性相互作用驱动的意想不到的,复杂的多孔晶格自我组装的观察.
- 对自组装捆绑器的结构状面中心立方包装安排的识别.
结论:
- 具有战略位置的反应组的工程捆绑可以创建复杂的基于的材料.
- 对功能组显示的精确控制允许微调网络属性,并将其定向自组装到复杂架构中.
- 这种方法为设计新型材料提供了一个多功能平台,为各种应用提供了量身定制的功能.
相关概念视频
Formation of Higher-order Actin Filaments
3.0K
The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin...
The high-order actin...
3.0K
Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
Protein Networks
3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Assembly of Cytoskeletal Filaments
18.6K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
18.6K
Protein Complex Assembly
10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.6K
Cytoskeletal Linker Proteins - Plakins
2.3K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
2.3K


