重视骨折风险:骨矿物质密度T分数和2型糖尿病中骨折风险
V Van Hulten1,2,3, J H M Driessen1,3, S Andersen4
1Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.
Diabetes, obesity & metabolism
|September 4, 2024
概括
部部骨矿物密度T分数有效预测2型糖尿病患者和没有2型糖尿病患者的骨折风险. 无论糖尿病状况如何,骨折风险和预测能力在各组都相似.
科学领域:
- 内分泌学和新陈代谢学
- 整形外科 整形外科 整形外科
- 老年学是一门学科.
背景情况:
- 2型糖尿病 (T2D) 与骨折风险增加有关.
- 部部 (FN) 骨矿物密度 (BMD) T-分数在预测T2D患者骨折中的作用尚未完全理解.
研究的目的:
- 调查FN BMD T-score与骨折风险之间的关联.
- 通过FN BMD T-score对患有和没有T2D的个体进行骨折风险预测的比较.
主要方法:
- 使用丹麦国家卫生服务数据的回顾性队列研究.
- 双能X射线吸收计用于FN BMD测量.
- 考克斯比例危险回归分析FN BMD T-score和骨折风险,经过对共变量进行调整.
主要成果:
- FN BMD T-score与男性和女性的部,非脊柱和主要骨质疏松性骨折有显著的相关性.
- 关于骨折风险的FN BMD T-score的预测能力在患有和没有T2D的个体中是相似的.
- 在T2D和没有T2D的个体之间,骨折发病率或10年累积骨折风险没有显著差异.
结论:
- FN BMD T-score是T2D和非T2D人群中各种骨折类型的重要预测因素.
- 骨折风险和FN BMD T-score的预测能力在患有和没有T2D的个体之间是可比的.
- 糖尿病状态不会改变FN BMD T-score和骨折风险之间的关系.
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