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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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相关实验视频

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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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化学素在免疫力中的作用

Mattia Laffranchi1, Tiziana Schioppa2,3, Francesca Sozio1

  • 1Department of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur-Fondazione Cenci Bolognetti, Viale Regina Elena 291, 00161 Rome, Italy.

Journal of leukocyte biology
|September 4, 2024
PubMed
概括
此摘要是机器生成的。

化学素是一种参与免疫反应的蛋白质,充当阿迪波金和血管生成因子. 它的活性由基因表达,蛋白质处理和受体相互作用调节,影响免疫细胞功能.

关键词:
在CCRL2中使用.在CMKLR1中,癌症 癌症 癌症 癌症 癌症化学 化学 化学 化学 化学 化学 化学这是一种炎症炎症炎症炎症.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.
  • 细胞生物学 细胞生物学

背景情况:

  • 化学素,一个囊胺家族成员,作为一种化学作用,脂肪生成和血管生成因子.
  • 它的生物活性是由基因表达,蛋白质加工和受体结合来调节的.
  • 化学素是由树皮细胞产生的,并以一种需要激活的无活性生殖原体的形式循环.

研究的目的:

  • 审查化学素在调节免疫反应中的作用.
  • 探索化学素与其受体的相互作用及其对免疫细胞的影响.

主要方法:

  • 对化学素的生物功能和免疫系统调节研究的文献综述.
  • 对化学素与化学素1 (ChemR23/CMKLR1),GPR1和CCRL2受体的相互作用进行分析.

主要成果:

  • 化学素与Chemerin1 (ChemR23/CMKLR1) 结合在诸如巨细胞和树突细胞等先天性免疫细胞上.
  • 化学素还与屏障细胞上的GPR1和CCRL2受体相互作用,影响白细胞迁移.
  • 化学素的激活和受体结合对于其在免疫中的生物功能至关重要.

结论:

  • 化学素通过与各种受体的相互作用,在调节免疫反应方面发挥着重要作用.
  • 了解化学素的功能对于开发针对免疫相关疾病的新疗法至关重要.