维生素D受体基因多态性与肺结核易感性之间的关联:系统性审查和元分析
Rongshan Tao1, Shujuan Xiao2, Lianping Wang3,4
1The Key Laboratory of Environmental Pollution Monitoring and Disease Control, School of Public Health, Ministry of Education, Guizhou Medical University, Guiyang, China.
Frontiers in genetics
|September 4, 2024
概括
维生素D受体 (VDR) 基因多态性,特别是FokI,与HIV阴性个体肺结核 (TB) 风险增加有关. 这表明维生素D补充剂可能在结核病预防策略中发挥作用.
科学领域:
- 遗传学和免疫学 遗传学和免疫学
- 传染病流行病学 传染病流行病学
- 营养科学 营养科学
背景情况:
- 结核病 (TB) 仍然是全球主要的健康威胁.
- 维生素D缺乏与结核病易感性有关.
- 维生素D受体 (VDR) 基因中的多态性可能会影响结核病风险,但之前的发现是不一致的.
研究的目的:
- 进行一项元分析,研究VDR基因多态化与HIV阴性个体的结核病易感性之间的关联.
- 为了澄清以前关于VDR多态性和结核病风险的研究中不一致的结果.
主要方法:
- 在PubMed,Embase和Medline数据库进行系统的文献搜索,截至2022年12月31日.
- 纳入标准集中在艾滋病毒阴性人群.
- 计算了95%置信区间 (CI) 的聚合几率 (OR);使用纽卡斯尔-太华尺度评估研究质量;通过子组和元回归分析探索异质性.
主要成果:
- 在VDR基因中的FokI多态性与allele (f与F:OR=1.235,95%CI:1.035-1.475) 和衰退基因型 (ff与Ff+FF:OR=1.317,95%CI:1.005-1.727) 模型中的TB易感性增加有关.
- 亚组分析显示,在汉族中国人群中的所有基因型模型中,FokI多态与结核病风险的关联.
- 超回归确定了种族为FokI和BsmI多态的异质性的潜在来源,以及TaqI多态的出版年.
结论:
- 在VDR基因中的FokI多态性与艾滋病毒阴性人群,特别是亚洲人群中结核病风险增加有关.
- 这些发现可能会为结核病预防策略提供信息,可能涉及维生素D补充剂,这一话题需要进一步调查.
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