与睡眠相关的呼吸障碍在多系统缩患者中的患病率和影响:一个横截面研究和元分析
Hui Wang1, Ting Zhang1, Wenhui Fan1
1Department of Neurology, Sichuan Taikang Hospital, Chengdu, Sichuan, China.
Frontiers in neurology
|September 4, 2024
概括
与睡眠相关的呼吸障碍 (SRBD) 影响了78.8%的多系统缩 (MSA) 患者,主要是阻塞性呼吸暂停. 在地理上,SRBD的患病率有所不同,在亚洲比欧洲更高,但不会显著影响MSA症状.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
背景情况:
- 与睡眠相关的呼吸障碍 (SRBD) 是多个系统缩 (MSA) 中常见的非运动症状.
- 之前的研究报告了在MSA中SRBD的不一致的流行率.
- 有限的研究已经探索了SRBD对MSA患者运动和非运动症状的影响.
研究的目的:
- 为了确定中国可能的MSA患者队列中SRBD的患病率.
- 调查SRBD与临床特征之间的关联,包括MSA中的运动和非运动症状.
- 进行元分析,以确定全球MSA中SRBD的总体流行率,并探索区域差异.
主要方法:
- 一项涉及66名可能患有MSA的患者的横截面研究,这些患者接受了SRBD评估的多睡眠图 (PSG).
- 患者使用标准化的睡眠 (ESS),MSA严重程度 (UMSARS),抑郁 (HAMD),焦虑 (HAMA),认知功能 (MMSE),非运动症状 (NMSS) 和睡眠质量 (PSQI) 的标准秤进行评估.
- 对MSA和SRBD发表的研究进行了系统的元分析,使用主要的科学数据库 (PubMed,科学网,Embase,Cochrane).
主要成果:
- 在研究的66名MSA患者中,78.8%的人被诊断出SRBD.
- 患有SRBD的MSA患者表现出明显更高的阻塞性呼吸暂停和打指数,以及较低的夜间平均和最低氧气和水平.
- 对295名MSA患者的元分析显示,SRBD的总体患病率为60.5%,亚洲 (79.2%) 的患病率明显高于欧洲 (41.6%).
结论:
- 在MSA患者中,SRBD的流行率很高,主要是阻塞性类型.
- 在SRBD患病率存在地理差异,在亚洲人群中观察到的比率更高.
- 在这项研究中,SRBD的存在与MSA患者的运动或非运动症状的严重程度没有显著的相关性.
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