根据住院COVID-19患者的发烧状况,血液学,凝血和炎症标志物的变化:一项回顾性研究
Bijoya Chatterjee1, Nikunj Modi1, Khushi Desai2
1Department of Biochemistry, Shri MP Shah Government Medical College, Jamnagar, Gujarat, India.
Journal of family medicine and primary care
|September 4, 2024
概括
COVID-19患者的发烧与血液计数和凝固因子的显著变化有关. 关键标记物,如C-反应蛋白和D-二次体,可以帮助识别患有发烧的患者.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 临床化学 临床化学
背景情况:
- 实验室标记物如淋巴缺血症,血小板缺血症,D-二次数升高和C反应蛋白 (CRP) 是已知的预测者,在2019年冠状病毒病 (COVID-19) 中预测不良结果.
- 目前缺乏有关COVID-19患者发烧状况的血液学和凝血参数变化的详细分析.
研究的目的:
- 综合分析COVID-19患者血液学,凝血和炎症标志物的变化,基于发烧的存在或不存在.
- 确定主要的实验室参数,预测COVID-19中的发烧状况.
主要方法:
- 对300名住院COVID-19患者进行了回顾性分析.
- 患者被分为两组:发烧 (n=200) 和没有发烧 (n=100) 的患者.
- 血液学,凝血和炎症标志物在各组之间进行了比较,并使用多变量回归来确定发烧的独立预测因子.
主要成果:
- 在COVID-19患者中,发烧与白细胞症,中性恋,淋巴缺血,血小板缺血以及CRP,D-二次体,公素,中性素与淋巴细胞比率 (NLR) 和费里丁的水平升高有关.
- 升高的D-二聚合物,CRP,NLR和互白素-6与发烧的相关性最强.
- 高D-二聚合物,CRP,淋巴缺血,NLR和血小板缺血被确定为发烧状况的显著独立预测因素,显示出中度敏感性和高特异性.
结论:
- 在患有发烧的COVID-19患者中观察到血液学,凝血和炎症标志物的显著变化.
- 常规实验室参数可以帮助COVID-19患者的诊断和风险分层.
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