口服营养补充剂和体育炼干预措施对老年人沙科佩尼亚风险的影响
Thiago J M Gonçalves1, Bruna T Carlos1, Mayara S de Souza1
1Nutrology and Clinical Nutrition, Sancta Maggiore Hospital, Prevent Senior Institute, São Paulo, Brazil.
Journal of frailty, sarcopenia and falls
|September 4, 2024
概括
这项研究发现,将口服营养补充剂与抵抗训练相结合,可以改善老年人肉类症风险的肌肉质量,力量和运动能力.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 营养科学 营养科学
- 运动生理学 运动生理学
背景情况:
- 骨肌肉质量的疾病萨尔科佩尼亚,以肌肉强度和质量下降为特征.
- 老年人特别容易患上 sarcopenia,影响他们的整体健康和独立性.
研究的目的:
- 评估12周联合干预对老年人骨肌肉质量 (SMM),强度和功能的影响.
- 评估口服营养补充剂 (ONS) 和力量训练 (RET) 在缓解肉症方面的有效性.
主要方法:
- 对涉及高龄成年人患有肉症风险的干预方案的回顾性分析.
- 参与者每天接受ONS,并在12周内每周三次参加RET.
- 测量包括小牛周长 (CC),生物电阻分析 (BIA),手握强度 (HGS) 和定时启动和启动 (TUG) 测试.
主要成果:
- 观察到CC (1.9 ± 2.5厘米,p < 0.001),强度 (5.4 ± 2.1 公斤,p < 0.001),无脂肪质量 (1.0 ± 1.3 公斤,p < 0.001) 和SMM (0.9 ± 0.5 公斤,p < 0.001) 的显著增加.
- 观察到TUG测试时间显著减少 (-2.4 ± 4.8秒,p = 0.001),表明移动性得到改善.
- 这项研究包括51名老年人 (平均年龄76.3±8.3岁,68.6%是女性).
结论:
- 与ONS和RET结合的营养干预有效地增加了老年人肌肉强度,SMM和功能,这些老年人面临着沙科佩尼亚的风险.
- 这种干预策略对管理和潜在地扭转老年人群中与肉症相关的下降有希望.
相关概念视频
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Exercise and Muscle Performance
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...


