通过结构方程建模,检查布诊所参与者的身体虚弱循环
Román Romero Ortuño1,2, Eoin Duggan1,2
1FRAILMatics research group, Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Journal of frailty, sarcopenia and falls
|September 4, 2024
概括
这项研究使用结构方程建模验证了老年人虚弱周期 (CF). 虽然一些途径得到了支持,但需要进一步的研究才能在临床环境中完全证实CF假设.
科学领域:
- 老年学是指老年学的学科.
- 临床医学 临床医学
- 生物统计学 生物统计学
背景情况:
- 1998年提出的虚弱循环 (CF) 假设缺乏广泛的验证,尽管已经确立了物理虚弱表型 (FP).
- 了解虚弱路径对于老年人的干预至关重要,特别是那些参加摔倒诊所的人.
研究的目的:
- 使用结构方程建模 (SEM) 内部验证脆弱性循环 (CF) 假设.
- 通过使用50岁以上成年人的临床数据,检查CF内的因果途径.
主要方法:
- 结构方程建模 (SEM) 用于来自门诊倒诊所的102名老年人 (平均年龄69.8岁) 的数据集.
- 这些指标包括年龄,发病率,营养,肉,VO2max,手握强度,基础代谢率 (BMR),5次椅子站测试 (5CST),体力活动和总能耗 (TEE).
主要成果:
- 该SEM模型显示总体支持 (p = 0.189),发现了对病率和年龄影响萨科佩尼亚的显著途径,萨科佩尼亚影响VO2max和手握强度,手握强度影响5CST.
- 身体活动影响了TEE,这反过来影响了营养,BMR影响了TEE.
- 一些假设的途径,包括营养影响的肉症和影响5CST的VO2max,在统计学上并不显著 (p <0.05).
结论:
- 该研究在老年人临床人群中为虚弱循环 (CF) 假设提供了部分内部支持.
- 限制包括对某些CF组件使用替代措施.
- 通过综合的脆弱性测量进行进一步的验证是有必要的,以确认CF的因果途径.
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