在墨西哥蒂华纳检测到西拉:三角化药物检查和临床尿液检测数据
Joseph R Friedman1,2, Alejando González Montoya3, Carmina Ruiz3
1Department of Psychiatry, University of California, San Diego.
medRxiv : the preprint server for health sciences
|September 4, 2024
概括
西拉在墨西哥蒂华纳普遍存在,在超过80%的非法阿片类药物使用者的尿样中检测到. 药物样本中的利多卡因可能会干扰西拉试验条,需要进一步研究.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 药物使用研究研究 药物使用研究
背景情况:
- 与非法芬太尼一起,越来越多地检测到西拉 (一种兽医麻醉剂),这构成了新的公共卫生风险.
- 墨西哥边境城市是毒品贩运的关键枢纽,对新型物质 (如西拉) 的监控有限.
研究的目的:
- 调查西拉和其他物质在墨西哥蒂华纳的流行情况.
- 评估药物测试条的准确性,并识别潜在的干扰.
主要方法:
- 来自23名非法阿片类药物使用者的尿液和器械样本使用西拉,芬太尼和其他药物测试条进行了测试.
- 配件样本经过了确认性质谱分析.
主要成果:
- 在82.6%和65.2%的尿样和65.2%和47.8%的器具样本中检测到西拉.
- 质谱测量证实了52.2%的克西拉阳性,并确定了芬太尼,芬太尼,特拉马多尔和利多卡因.
- 利多卡因在西拉试验条上引起了假阳性,而假阴性是最小的.
结论:
- 克西拉存在于美墨边境,需要进行公共卫生干预.
- 利多卡因的干扰使得使用试验条复杂化了用试验条检测氨酸的检测.
- 需要进一步的研究来验证药物检查计划中毒学测试方法的有效性.
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