相关实验视频
Updated: Jun 14, 2025
08:30
Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
Published on: April 19, 2011
21.6K
内源性腺是心血管--代谢综合征的潜在驱动因素
Ian Tamayo1, Hak Joo Lee1, M Imran Aslam2
1Center for Precision Medicine, University of Texas Health San Antonio.
medRxiv : the preprint server for health sciences
|September 4, 2024
概括
内源性腺积累导致心力衰竭和缺血性心脏病在心血管--代谢综合征. 抑制甲基腺酸酶 (MTAP) 逆转心脏功能障碍并防止损伤.
科学领域:
- 心血管科学 心血管科学
- 代谢学 代谢学 代谢学
- 分子生物学分子生物学
背景情况:
- 心血管--代谢 (CKM) 综合征的机制尚不清楚,但小分子代谢物可能起作用.
- 氨酸是一种关键的代谢物,与心血管疾病有关.
研究的目的:
- 为了研究腺素在CKM综合征的发病过程中的作用.
- 探索腺因作为心力衰竭和缺血性心脏病的潜在治疗点.
主要方法:
- 利用了批量和空间代谢学,单核基因表达,以及体内小鼠和老鼠模型.
- 评估了腺水平,甲基腺酸酶 (MTAP) 表达和心脏功能.
- 研究了MTAP抑制对腺积累和心脏结果的影响.
主要成果:
- 在糖尿病和左心室缩患者的冠状动脉血管中,腺被上调和丰富.
- 在患有多变性心肌病的人类心脏和心脏病的小鼠模型中观察到MTAP表达的增加.
- 抑制MTAP降低了腺水平,恢复了糖尿病小鼠的心脏功能,并预防了大鼠心肌梗塞.
- 氨酸诱导的髓功能障碍与mTOR信号相关,并通过其减少而逆转.
结论:
- 内源性腺是CKM综合征中的心力衰竭和缺血性心脏病的因果因素.
- MTAP是腺积累中的关键酶,也是CKM相关心血管疾病的潜在治疗点.
更多相关视频
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
11.7K
07:52A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
20.4K
相关概念视频
01:17Hormonal Regulation of Blood Pressure
2.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.5K
01:21External Anatomy of the Kidney
885
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
885
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
476
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
476
01:13Introduction to Urinary System
2.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.3K
01:33Hormonal Regulation
33.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.0K
01:18Hypertension and Regulation of Blood Pressure
2.0K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.0K