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在 Doxy-PEP 符合条件的人群中表现出四环素耐药性和共耐药性
Rachel Mittelstaedt1,2, Sanjat Kanjilal3,4, David Helekal2
1Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
medRxiv : the preprint server for health sciences
|September 4, 2024
概括
对于男性的黄金葡萄球菌感染,多西环素暴露后预防 (doxy-PEP) 可能会增加对多种抗生素的耐药性. 监测对于监测这种新出现的细菌感染威胁至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
- 公共卫生 公共卫生
背景情况:
- 黄金葡萄球菌感染是符合多西环林暴露后预防 (doxy-PEP) 资格的男性的担忧.
- 在S. aureus中,四环素不敏感性在这个人群中比一般人群中更为常见.
研究的目的:
- 在有资格接受doxy-PEP的男性中调查四环素对黄金葡萄球菌不敏感的流行率.
- 评估四环素不敏感性和对其他抗生素的耐药性之间的关联.
主要方法:
- 从有资格接受doxy-PEP的男性中分离出的金黄色葡萄球菌的分析.
- 对抗菌素敏感性测试以确定耐药性模式.
主要成果:
- 在接受doxy-PEP的男性中,S. aureus中环素不敏感性更为普遍.
- 这种不敏感性与对trimethoprim-sulfamethoxazole和clindamycin的耐药性有关.
结论:
- 多西-PEP可能会推动对多种药物耐药的黄金菌株的选择.
- 持续的监测对于监测和管理与doxy-PEP使用相关的抗菌素耐药性至关重要.
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