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美国成年人的表观遗传衰老加速和死亡风险预测
Angelico Mendy1, Tesfaye B Mersha2
1Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH.
medRxiv : the preprint server for health sciences
|September 4, 2024
概括
通过各种表观遗传时钟测量的表观遗传年龄加速 (EAA) 预测死亡率. 格里姆表观遗传时钟显示出与整体和心血管死亡率的最强相关性,而汉努姆和霍瓦斯时钟也预测了癌症死亡率.
科学领域:
- 衰老的生物标志物
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 预测死亡率的预测.
背景情况:
- 表观遗传钟测量生物年龄,并预测死亡率.
- 表观遗传衰老加速 (EAA) 是评估健康的新型指标.
- 不同的表观遗传钟可能为死亡结果提供不同的预测能力.
研究的目的:
- 评估EAA从多个表观遗传钟对长期整体,心血管和癌症死亡率的预测能力.
- 为了比较9个不同的表观遗传钟在预测死亡率方面的表现.
- 评估尼丁PoAm的老龄化速度与死亡率的关联.
主要方法:
- 从NHANES (1999-2002) 对2,105名美国成年人 (≥50岁) 的分析,死亡率随访至2019年.
- 使用九个表观遗传时钟 (Horvath,Hannum,SkinBlood,Pheno,Zhang,Lin,Weidner,Vidal-Bralo,Grim) 的残留物来计算EAA,这些时钟按时间年龄回归.
- 考克斯比例危险回归用于估计EAA和DunedinPoAm的危险比率,对死亡率结果的衰老速度进行调整,并对共变量进行调整.
主要成果:
- 在17年半的时间里,998人死亡. 格林EAA强烈预测了整体死亡率 (HR: 1.50) 和心血管死亡率 (HR: 1.55).
- 汉纳姆,霍瓦斯和格林EAAs预测了癌症死亡率 (HRs从1.24到1.37).
- 老化速度与整体 (HR: 1.23) 和心血管死亡率 (HR: 1.25) 的增加有关.
结论:
- 灰色EAA是整体和心血管死亡率的强有力的预测指标.
- 多个表观遗传时钟 (Horvath,Hannum,Pheno,Vidal-Bralo,Grim) 预测了整体死亡率.
- 老龄化指标的节奏也显示出与死亡风险的显著关联.
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