在嗅觉神经母细胞瘤中DOTATATE PET成像和与SSTR表达的关联
Daniel E Palmieri1, Kent S Tadokoro2, Benita Valappil2
1University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Journal of neurological surgery. Part B, Skull base
|September 4, 2024
概括
所有的嗅觉神经母细胞瘤 (ONBs) 都表达体静止素受体 (SSTRs),表现出DOTATATE狂热. 这表明Ga-68 DOTATATE PET/CT是监测复发性和转移性嗅神经母细胞瘤的有价值的成像工具.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 放射学 放射学是一门学科.
背景情况:
- 嗅觉神经母细胞瘤 (ONB) 是一种罕见的鼻腔瘤.
- 索马托斯塔丁受体 (SSTRs) 经常在ONB中表达.
- Ga-68 DOTATATE PET/CT 是对ONB的潜在成像方式.
研究的目的:
- 评估Ga-68 DOTATATE PET/CT在嗅觉神经母细胞瘤患者中的功效.
- 评估ONB.中SSTR2表达和DOTATATE狂热之间的相关性.
主要方法:
- 对于ONB的96个内镜内鼻骨底手术病例的回顾性审查.
- 测量了基因组 (H) 评分和正常化的DOTATATE标准化摄取值 (nSUV).
- 其中包括9名ONB患者.
主要成果:
- 所有纳入的ONB都显示出正的SSTR2表达 (平均H分数:180).
- 所有的ONB都表现出DOTATATE热情 (平均nSUV:6.7).
- 在H分数和nSUV之间没有发现显著的相关性 (r2 = 0.24,p = 0.18).
结论:
- 在ONB中SSTR2表达始终存在.
- 在所有ONB中观察到DOTATATE贪.
- 在监测复发性和转移性ONB时,Ga-68 DOTATATE PET/CT可能是一个有价值的成像工具.
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