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Updated: Jun 14, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

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表观遗传调节者的功能映射揭示了由HBO1和MLL1复合体协调的瘤抑制

Yuning J Tang, Haiqing Xu, Nicholas W Hughes

    bioRxiv : the preprint server for biology
    |September 4, 2024
    PubMed
    概括

    研究人员确定了新的表观遗传调节剂,HBO1和MLL1复合体,对于抑制肺癌至关重要. 这些复合物控制基因表达和染色质可访问性,为肺腺癌提供新的治疗点.

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    HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries10:10

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    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution13:47

    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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    相关概念视频

    Epigenetic Regulation01:37

    Epigenetic Regulation

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    Abnormal Proliferation02:23

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    The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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