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猪的发育和初始特征与DNAI1 突变和初级状腺功能障碍

Mahmoud A Abou Alaiwa1,2,3, Brie M Hilkin1, Margaret P Price1

  • 1Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.

bioRxiv : the preprint server for biology
|September 4, 2024
PubMed
概括

研究人员通过破坏DNAI1基因,开发了一种用于原发性纤毛功能障碍症 (PCD) 的猪模型. 这种模型表现出关键的PCD症状,为了解和治疗这种罕见的遗传疾病提供了新的途径.

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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