更多的相似性比差异:比较早期青少年大脑结构的性别内和性别之间的差异
Carinna Torgerson1,2, Katherine Bottenhorn1, Hedyeh Ahmadi1
1Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
bioRxiv : the preprint server for biology
|September 4, 2024
概括
青少年大脑研究往往高估了性别差异. 这项研究揭示了男性和女性之间大脑结构的相似之处多于差异,强调了神经成像中差异分析的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 人类解剖学 人类解剖学
背景情况:
- 目前青少年神经成像研究主要集中在性别之间的平均差异上.
- 这种方法可能会导致在发育中的大脑中高估性别差异和性二态.
- 需要对相对分布和相似性进行更深入的研究.
研究的目的:
- 描述青春期早期关于出生时性别的大脑宏观和微观结构的变异.
- 分析性别内部和性别之间的差异,分布重叠和差异异异同质性.
- 为了研究这些差异,使用原始和残留的大脑估计.
主要方法:
- 利用了来自青少年大脑认知发展 (ABCD) 研究 (9-11岁) 的大量样本 (N=7,723).
- 检查了全球和区域灰色/白质体积,皮质厚度和白质微观结构 (微分异构,平均扩散性).
- 雇佣的Fligner-Killeen测试用于差异的同质性和ANOSIM用于相似性,控制年龄,青春期状态和社会经济地位等共变量.
主要成果:
- 男性和女性大脑结构分布之间的重叠始终大于差异.
- 在所有皮层和皮层下体积中观察到显著的异质差异.
- 剩余的结果显示了更大的重叠和更小的性别差异,表明在控制共变量后更大的相似性.
结论:
- 早期青少年大脑结构中的性别差异可能源于差异差异,而不是独特的表型.
- 这些发现挑战了高度性别二态大脑的概念,显示出更多的相似性而不是差异.
- 强调考虑大脑结构的性别差异研究中的差异的关键作用.
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