大脑结构和活动预测青春期的认知成熟
Junda Zhu1, Clément M Garin2,3, Xue-Lian Qi4
1Program in Neuroscience, Vanderbilt University, Nashville TN 37235 USA.
bioRxiv : the preprint server for biology
|September 4, 2024
概括
子青少年大脑发育表明,前额叶皮层神经活动的变化,不仅仅是大脑大小,推动了像工作记忆这样的认知改进. 长距离大脑连接的成熟是这种神经认知发展的关键.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 灵长类的认知能力
背景情况:
- 在灵长类动物 (包括人类) 中,认知能力在整个青春期都在发展.
- 已知大脑结构和连接性的变化,但它们对神经元活动和认知功能的影响尚不清楚.
研究的目的:
- 用多层次的纵向方法研究子中的青少年神经认知发育.
- 了解神经元活动的变化如何与青春期的认知改善有关.
主要方法:
- 对子青少年神经认知发育的纵向研究.
- 对前额叶皮质神经活动的分析.
- 神经活动和认知表现与大脑结构变化 (体积,厚度,白质道) 的相关性.
主要成果:
- 前额叶皮层神经活动轨迹预测工作记忆的改善.
- 复杂的神经活动变化 (例如,刺激表示旋转) 和简单的属性 (例如,基线发射率) 是预测性的.
- 大脑体积/厚度的减少没有预测神经或认知变化.
- 长距离白质的成熟会导致神经活动和行为的最佳预测变化.
结论:
- 在分布式电路中优化神经活动是青少年认知发展的基础.
- 大脑的结构变化,特别是白质的成熟,对于精炼神经活动和认知功能至关重要.
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