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解开非化STAT3-非化NF-κB通路在功能丧失中的STAT3超IgE综合征

Adil Karim1, Rashi Garg1, Biman Saikia1

  • 1Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Frontiers in immunology
|September 4, 2024
PubMed
概括

与转录3相关的超IgE综合征 (LOF STAT3 HIES) 的信号传感器和激活器功能丧失涉及非正规STAT3信号的受损. 这项研究揭示了减少RANTES和STAT3的表达,突出了它们在HIES病原发生中的作用.

关键词:
过高IgE综合征 (HIES) 是一种在激活时受到监管.免疫的先天性错误 (IEI)正常T细胞表达和分泌的化学激素 (RANTES)核因子卡帕b (NFκB) 是一个核因子.一次性免疫缺陷 (PID)信号传感器和转录3 (STAT3) 的激活器

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