相关实验视频
Updated: Jun 14, 2025

08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
15.7K
超越刀:在不可解释的黑色素瘤中推进战略方法和向治疗
Vivian Li1, Kelly Frasier1, Julia Vinagolu-Baur2
1Nuvance Health, Vassar Brothers Medical Center, Poughkeepsie, NY 12601, USA.
Journal of skin cancer
|September 4, 2024
概括
非手术治疗,如局部药物和免疫疗法,为挑战性黑色素瘤提供了新的希望. 然而,需要标准化的指导方针来优化对这些难以治疗的皮肤癌的护理.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 医学研究 医学研究
背景情况:
- 黑色素瘤在困难的解剖部位 (面部,部,粘膜) 复杂化了手术切除.
- 目前的治疗指南缺乏针对这些特定位置的全面方案.
研究的目的:
- 审查复杂解剖部位黑色素瘤的非手术治疗方法.
- 确定当前指南中的差距,并评估现有疗法的疗效.
主要方法:
- 在PubMed,Embase和Web of Science的综合文献搜索.
- 在具有挑战性的领域选关于黑色素瘤非手术治疗的同行评审文章.
- 对局部药物,免疫疗法,放射疗法和向疗法的分析.
主要成果:
- 局部治疗方法,如伊米基莫德和内伤性塔利摩根拉赫帕雷维克 (T-VEC),对无法切除的黑色素瘤有希望.
- 系统疗法 (BRAF/MEK 抑制剂,检查点抑制剂) 提高了生存率,但具有耐药性和副作用.
- 放射治疗是一种辅助策略,因为黑色素瘤的放射电阻.
结论:
- 存在重大进展,但在具有挑战性的位置缺少黑色素瘤的基于证据的协议.
- 迫切需要标准化指导方针来解决疗效,副作用和心理社会影响.
- 未来的研究应该专注于改进治疗方法和开发创新的方法,以改善患者的治疗结果.
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Skin Cancer
4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493

