在儿童接种COVID-19疫苗后的心肌炎:系统性审查和元分析
Ashiley Annushri Thenpandiyan1, Ryan Ruiyang Ling1, Robert Grignani1,2
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Singapore medical journal
|September 4, 2024
概括
在儿童接种COVID-19疫苗后心肌炎的风险很低,每百万剂量中有19.8例. 青少年,男性和接受第二剂疫苗的人面临更高的风险.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 儿科 儿科 儿科
背景情况:
- 心肌炎是一种罕见但严重的不良事件,与2019年新冠肺炎 (COVID-19) 疫苗接种相关,主要在青少年中观察到.
- 随着COVID-19疫苗接种扩展到年轻年龄组,了解相关风险至关重要.
研究的目的:
- 在19岁以下的个人中进行信使核糖核酸 (mRNA) COVID-19 疫苗接种后心肌炎风险的元分析.
- 为了确定患有心肌炎的儿科患者群体中的高危子组.
主要方法:
- 在MEDLINE,Embase和Scopus数据库中进行了系统的搜索,搜索到2022年8月1日之前发表的观察性研究.
- 进行了随机效应元分析,以确定与儿科COVID-19疫苗接种有关的心肌炎,心肌炎和心周炎的发病率.
主要成果:
- 分析包括12项研究,涵盖超过5900万剂疫苗,显示每百万小儿剂量中有19.8例心肌炎病例.
- 儿童的发病率与成年人相当 (23.7例/百万剂量).
- 在第二剂疫苗接种后,在男性和12岁及以上儿童中观察到更高的风险.
结论:
- 在儿童接种mRNACOVID-19疫苗后,心肌炎的总体风险较低,与成人相似.
- 特定的子组,包括青少年,男性和第二剂疫苗接种者,表现出更高的风险概况.
- 研究结果支持有关儿童COVID-19疫苗接种策略的知情决策.
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