探索纳尔布芬装载的奇托桑纳米颗粒通过鼻内注射有效治疗疼痛:一项比较性研究
Kushagra Khanna1,2, Nitin Sharma3, Ritu Karwasra4
1Department of Pharmaceutics, Delhi Pharmaceutical Science and Research University, New Delhi, India.
Journal of drug targeting
|September 4, 2024
概括
使用奇托纳米颗粒进行鼻腔输送纳布芬,成功实现了显著的脑药物可用性. 与标准治疗相比,这种鼻入配方显示出更高的疼痛控制效果.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 神经科学是一个神经科学.
背景情况:
- 鼻内药物输送提供了一个有前途的途径,可以直接进入大脑.
- 嗅觉和三叉体通道是脑内鼻腔输送的关键通道.
研究的目的:
- 开发和评估一种用于有效地向大脑输送纳尔布芬的鼻腔配方.
- 通过有针对性的大脑分布来增强纳尔布芬的治疗潜力.
主要方法:
- 使用离子凝制备装载有纳布芬的奇托桑纳米颗粒.
- 纳米粒子的特点是大小,形状,泽塔潜力和捕获效率.
- 进行了体外药物释放,体外安全性,体内疗效和药理学研究.
主要成果:
- 获得了具有高捕获效率 (88.43%) 的球形纳米粒子 (192.4 ± 11.6 nm).
- 试验室研究显示了双相释放特征,试验室/体内研究证实了配方的安全性.
- 在体内研究表明,有效的脑输送,优越的疼痛管理效果超过市场配方,和大脑保留.
结论:
- 基托桑纳米颗粒提供了一种有效的系统,用于将纳尔布芬鼻内输送到大脑.
- 开发的配方显示了改善疼痛管理和直接针对大脑的显著潜力.
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