长期使用质子抑制剂对功能障碍和骨脆弱性的影响
Yianni Protopapadakis1, Hayden Shuster2, Austin B Bambach1
1Department of Medicine, Prisma Health Upstate, Greenville, SC, USA.
The Annals of pharmacotherapy
|September 4, 2024
概括
长期使用质子抑制剂 (PPI) 与更高的骨质疏松症,骨质疏松症和慢性病 (CKD) 率有关. 这些发现表明,延长PPI治疗超过推持续时间可能存在潜在风险.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 建议使用质子抑制剂 (PPI) 来治疗短期胃食道逆流性疾病 (GERD).
- 长期使用PPI适用于特定疾病,但具有记录的不良影响.
- 新出现的证据将PPI与脏疾病和骨脆弱性联系起来.
研究的目的:
- 在使用PPI超过8周的患者中确定骨质疏松症,骨质疏松症和慢性病 (CKD) 的发生率.
- 评估长期PPI治疗与这些不良健康结果的发展之间的关联.
主要方法:
- 在一个单一的初级保健诊所进行的回顾性队列分析.
- 包括18-65岁的患者,他们的PPI处方超过8周.
- 收集有关PPI使用,人口统计和医疗诊断的数据.
主要成果:
- 该研究确定了293名PPI使用者和1908名非使用者.
- 使用PPI的人群出现骨质疏松症/骨质疏松症 (OR=2.91) 和CKD (OR=1.14) 的比率明显更高.
- 这些疾病的风险增加与更长的PPI持续时间,糖尿病,更高的BMI,黑人种族和男性性别有关.
结论:
- 长期使用PPI与骨质疏松症/骨质疏松症和CKD的发病率增加有关.
- 后勤回归证实,在使用PPI时,脏疾病和骨疾病的可能性更高.
- 这些发现有助于对长期PPI风险的证据基础,需要进一步研究.
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