固体瘤患者心血管死亡风险:美国的一项基于人口的研究
Shuaijie Gao1, Hao Zhu1, Xinyu Chang1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University.
患有固体瘤的患者面临更高的心血管疾病 (CVD) 死亡风险,这是非癌症死亡的重要原因. 早期查和风险管理对于预防癌症患者心血管疾病死亡至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 关于固体瘤中心血管疾病 (CVD) 特定死亡率的数据有限.
- 以前的研究集中在血液癌症和特定瘤部位上.
研究的目的:
- 系统地分析固体瘤患者心血管疾病特异性死亡的分布,风险和趋势.
- 评估固体瘤对心血管死亡率的影响.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 计划数据对2,679,293名被诊断为固体瘤的患者 (1975-2019) 进行了分析.
- 计算的标准化死亡率 (SMRs) 和绝对超额风险 (AERs) 对心脏病特异性死亡.
- 采用竞争风险回归和受限立方线分析来评估风险和与年龄相关的趋势.
主要成果:
- 在固体瘤患者中,心血管疾病特异性死亡占非癌症死亡的48.95%.
- 与普通人群相比,患有固体瘤的患者对心血管疾病,心脏病和脑血管疾病的SMR和AER显著更高.
- 随着时间的推移,在诊断后观察到SMR的下降趋势,与非线性年龄-心血管疾病死亡关系.
结论:
- 心血管疾病是固体瘤患者非癌症死亡的主要原因.
- 固体瘤患者患有心血管疾病特异性死亡风险较高,需要主动管理.
- 将心血管疾病查和风险管理纳入癌症护理可能会降低心血管疾病死亡率.
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