在炎症性肠道疾病中诊断和管理困难的闭膜菌
Byron P Vaughn1, Alexander Khoruts1, Monika Fischer2
1Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.
患有炎症性肠病 (IBD) 的患者面临更高的Clostridioides difficile感染 (CDI) 风险. 早期诊断和量身定制的管理对于预防CDI复发和改善IBD结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD) 患者有增加的Clostridioides difficile感染 (CDI) 风险,由于较高的殖民率和重叠症状,诊断复杂化.
- 标准的CDI风险因素,如抗生素使用,可能在IBD患者中缺席,这是由于微生物群失调.
- 将IBD患者从CDI试验中排除在外,导致诊断和管理方面的知识差距.
研究的目的:
- 提供对IBD患者CDI的诊断,治疗和预防的全面审查.
- 强调在IBD恶化中区分CDI与殖民化的重要性,以防止治疗延迟.
- 强调在C. difficile存在时需要评估潜在的IBD,无论CDI诊断如何.
主要方法:
- 对IBD中CDI现有文献的叙述性综述.
- 讨论诊断挑战,包括区分殖民和活跃感染.
- 分析治疗策略,包括延长抗生素疗程和预防措施.
主要成果:
- 将CDI与殖民区分开来,对于及时管理IBD和CDI至关重要.
- 延长抗CDI抗生素疗程可能会改善结果.
- 基于微生物群的疗法和贝兹洛托克苏马布在预防IBD患者的CDI复发方面表现有前途.
结论:
- IBD患者需要针对患者的CDI管理和预防方法.
- 考虑CDI预防策略对于IBD患者具有高复发风险至关重要.
- 有效的共同管理涉及将CDI与殖民区分开来,防止复发,并管理潜在的IBD.
更多相关视频
12:58A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
