药物治疗酒精使用障碍 在与酒精有关的诊断产生的出生人群中
Sarah C M Roberts1, Guodong Liu, Mishka Terplan
1From the Advancing New Standards in Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, CA (SCMR); Department of Public Health Sciences and of Pediatrics, Penn State College of Medicine, Hershey, PA (GL); and Friends Research Institute, Baltimore, MD (MT).
Journal of addiction medicine
|September 4, 2024
概括
很少有酒精使用障碍 (AUD) 的孕妇接受药物治疗. 需要进行研究来评估AUD治疗在怀孕期间的安全性和有效性.
科学领域:
- 产科和妇科 产科和妇科
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 治疗酒精使用障碍 (AUD) 的药物已被证明在成年人中有效,但关于其在怀孕期间使用的数据很少.
- 在怀孕期间未经治疗的AUD对父母和胎儿都有重大风险.
- 越来越多的临床和研究人员对评估AUD药物对孕妇的兴趣.
研究的目的:
- 确定与酒精有关的诊断的孕妇和产后个体中,被处方AUD药物的比例.
- 为了确定对这一群体开处方的AUD药物的类型.
主要方法:
- 2006-2019年国家私人保险索赔数据库 (Meritive MarketScan) 的分析.
- 包括25-50岁的分娩个体,他们在美国分娩了一个单独的婴儿.
- 在出生后一年内与酒精相关诊断的个体与AUD药物的处方数据相匹配.
主要成果:
- 在1,432,979个分娩人-婴儿二元组中,有2517个 (0.18%) 患有与酒精有关的诊断.
- 只有8.70%的酒精相关诊断患者接受了任何AUD药物,主要是分娩后.
- 加巴丁是最常被处方的药物 (4.69%),其次是二类药物用于戒断 (2.19%),纳尔特雷克松 (1.91%) 和迪苏尔菲拉姆 (1.39%).
结论:
- 在与酒精有关的诊断的孕妇和产后患者中,AUD药物的处方率非常低.
- 进一步的研究至关重要,以权衡在怀孕期间使用AUD药物的潜在益处与风险.
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