自主调制影响了传导速度动态和波面传播在左心室的自主调制
Shohreh Honarbakhsh1,2, Caroline Roney1, Caterina Vidal Horrach1
1Queen Mary University of London, London, UK.
概括
心房纤维化会影响心脏传导速度 (CV) 的动态. 自主调制,特别是状刺激,增加心血管异质性,改变心房动 (AF) 中的波面传播.
科学领域:
- 电子生理学 电子生理学
- 心脏病理生理学 心脏病理生理学
- 医疗成像医学成像
背景情况:
- 心房纤维化和自主神经系统重塑与心房的病理生理学有关.
- 了解这些因素对心脏电活动的影响对于开发有效的治疗方法至关重要.
研究的目的:
- 为了评估心房纤维化和自主调制对传导速度 (CV) 动态和心脏波传播的影响.
- 调查局部电压幅度,CV恢复和自主影响之间的关系.
主要方法:
- 当地激活时间 (LAT),电压和几何数据从54名因持续性AF而经历切除术的患者中收集.
- 心血管动力学被评估在三次节奏间隔的鼻节律.
- 确定了药理学 (阿特罗平,异上腺素) 和电力 (状刺激) 自主调节对心电脉动,波面传播和转点的影响.
主要成果:
- 心血管动力学受到当地的电压幅度的显著影响,在非低电压区域内心血管恢复曲线更.
- 异上腺素和状复合体刺激导致了更大的速度依赖性心血管减速和心血管异质性的增加.
- 高比例 (80.2%) 的确定的枢纽点 (波浪线传播的显著变化) 与取决于速率的CV减速地点同处.
结论:
- 前庭心血管动力学受到纤维化负荷的调节,影响电传播.
- 自主调制显著提高了心房心血管异质性,并改变了关键枢纽点的分布.
- 这项研究提供了关于自主重塑在AF病理生理学中的作用的见解.
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