人体内源逆转录病毒在先天免疫记忆中的潜在贡献
Pengcheng Du1, Jiarui Li2, Mingxi Hua2
1Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; and.
人体内源逆转录病毒 (HERVs) 在训练免疫力中发挥作用,这是免疫细胞获得长期炎症记忆的过程. 这项研究表明,HERVs调节基因表达和表观遗传修饰,这对于训练有素的免疫力至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 训练有素的免疫力通过先天免疫细胞中的长期炎症表型来增强宿主防御能力.
- 转录和表观遗传重编程是关键机制,但监管网络仍然不清楚.
- 人体内源逆转录病毒 (HERVs) 是丰富的基因组元素,具有潜在的调节功能.
研究的目的:
- 研究HERVs在训练有素和耐受性巨细胞中的作用.
- 在训练免疫的背景下,探索 HERVs 作为调节剂.
主要方法:
- 来自9项研究的公开可用的RNA测序和基因素修饰数据的分析.
- 检查HERV转录,表观遗传修饰和与基因表达的关联.
- 在差异表达基因和潜在增强剂区域附近识别HERVs.
主要成果:
- 15.3%的HERV被非随机转录,在特定的家族和染色体中进行丰富 (11,15,17,19),并与相邻的基因表达有关.
- 在142个差异表达基因附近发现了295个差异表达的HERV.
- 确定了35种类似增强剂的HERV,其中相关的基因参与炎症反应 (例如TLR途径).
结论:
- 在训练免疫中,HERVs被显著转录和表观遗传修饰.
- HERVs可能通过影响基因表达和炎症途径,充当训练免疫的关键调节者.
- 需要进行进一步的研究,以阐明HERVs在酸信号传递和营养物/离子运输中在训练免疫中所扮演的精确角色.
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