在新加坡,对帕金森病的亚thalamic核深度大脑刺激的长期结果
Yi Zhan Cai1, Yilong Zheng2, Wei Li3,4,5
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Annals of the Academy of Medicine, Singapore
|September 4, 2024
概括
亚thalamic核深度大脑刺激 (STN-DBS) 显著减少"关闭"时间和药物需求在帕金森病 (PD) 患者长期. 虽然运动分数最终会增加,但STN-DBS为PD管理提供了持续的好处.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 运动障碍 运动障碍
背景情况:
- 脑下核深度大脑刺激 (STN-DBS) 是帕金森病 (PD) 的一项成熟治疗方法.
- 它旨在缓解运动障碍等运动症状,减少药物依赖.
研究的目的:
- 评估STN-DBS在PD患者的长期疗效和安全性,直至手术后10年.
- 评估运动功能,日常生活活动 (ADL) 和药物需求的变化.
主要方法:
- 94名经过双边STN-DBS治疗的PD患者的回顾性审查.
- 运动障碍的分析 社会统一的帕金森病评分表 (MDS-UPDRS) 评分,ADL,疾病里程碑和不良事件.
主要成果:
- 在5年内,STN-DBS显著减少了"关闭"状态时间,长达40.9% (P=0.006).
- 利沃多巴每日相当剂量在5年内下降了35.1% (P<0.001).
- 从DBS后的5年开始,MDS-UPDRS运动和ADL得分增加;频繁下降在5年后增加.
结论:
- STN-DBS可持续缓解运动并发症,并减少新加坡PD患者的药物需求.
- 尽管长期增加了运动分数,但STN-DBS仍然是一个有效的治疗选择,改善了PD患者的生活质量.
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