关于急性移植对宿主病患者口服药物坚持的观点:一种定性描述性研究
Chiara Visintini1,2, Chiara Lucchetta3, Margherita Venturini4
1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Montpellier's Street, 1, 00133, Rome, Italy. chiara.visintini@students.uniroma2.eu.
概括
在移植对宿主疾病的全源干细胞移植后,免疫抑制剂的药物坚持是具有挑战性的. 患者制定个人策略来管理坚持,从义务过渡到习惯.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对免疫抑制剂 (IMMs) 的坚持对于治疗急性移植对宿主疾病 (aGvHD) 具有关键性的异构后造血干细胞移植 (HSCT).
- 在这种特定情况下,对患者药物坚持 (MA) 的经验存在有限的研究.
研究的目的:
- 探索与GvHD相关的全基性HSCT患者关于他们对口服免疫抑制疗法的药物坚持的观点.
- 了解与维持这种患者群体的坚持相关的挑战和策略.
主要方法:
- 一个使用反射主题分析的定性描述性研究.
- 涉及16名GvHD患者,他们在骨髓移植中心接受门诊护理.
- 通过半结构面试收集的数据,字面转录,并根据COREQ和ESPACOMP指南进行主题分析.
主要成果:
- 患者的观点揭示了从将坚持视为外部义务的转变到将其发展为一种习惯.
- 患者经历了IMM的双重影响,经历了系统的遵守失败,但采用了个人策略来改善遵守.
- 主要主题包括"从外部义务转变为习惯"",在IMM的负面和积极影响之间处于中间位置"",未能系统地遵守规则"和"采用个人策略来成为合规者".
结论:
- 在aGvHD患者中,药物坚持是复杂且经常具有挑战性的行为.
- 研究结果强调了医疗保健专业人员需要量身定制的策略和行为干预措施,以最大限度地提高患者对IMM的坚持.
- 了解患者的观点对于设计有效的坚持支持计划至关重要.
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