Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

36.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dysregulated methylation‒ubiquitination crosstalk accelerates intervertebral disc degeneration via MED12 destabilization and cGAS/STING activation.

The Journal of clinical investigation·2026
Same author

Spatiotemporal Dynamics and Assembly Mechanisms of Bacterial Communities in Tropical-Subtropical Coastal Waters of the Leizhou Peninsula, China.

Microorganisms·2026
Same author

Highly Sensitive and Robust Detection of Human Telomerase Based on Strand-Displacement Cascade Amplification.

ACS measurement science au·2026
Same author

Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE<sup>-/-</sup> mice via regulating estrogen receptor α.

Chinese medicine·2026
Same author

DiffDR: A Diffusion-based Deep Learning Framework for Accurate Drug Response Imputation and Feature Selection.

Current drug targets·2026
Same author

Halide doping and morphology engineering in bismuth-based MOFs for enhanced water oxygen evolution.

iScience·2026

相关实验视频

Updated: Jun 14, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K

一个基于对比学习的深度神经网络,通过整合多omics数据来进行癌症亚型识别.

Hua Chai1, Weizhen Deng1, Junyu Wei1

  • 1School of Mathematics and Big Data, Foshan University, Foshan, 528000, China.

Interdisciplinary sciences, computational life sciences
|September 4, 2024
PubMed
概括

这项研究引入了一种新的深度学习方法,用于使用多omics数据进行癌症亚型识别. 该方法准确地识别了不同的癌症亚型,改善了患者分层和预后预测.

关键词:
生物信息学是一种生物信息学.癌症亚型识别 癌症亚型识别相反的学习学习.多个omics数据数据的数据.

更多相关视频

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.7K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

989

相关实验视频

Last Updated: Jun 14, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.7K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

989

科学领域:

  • 计算生物学是一种计算生物学.
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 准确的癌症亚型确定对于预后和个性化治疗至关重要.
  • 多omics数据提供了洞察力,但面临着诸如高维度和小样本大小等挑战,导致模两可的亚型.
  • 现有的集群方法在与重叠的癌症亚型作斗争.

研究的目的:

  • 为癌症亚型开发一种基于对比学习的新型深度学习方法.
  • 为了应对高维度和小样本大小在患者集群的多omics数据中的挑战.
  • 提高已识别的癌症亚型的准确性和生物学意义.

主要方法:

  • 提出了一种端到端的深度学习方法,利用对比学习和自我监督学习.
  • 将该方法应用于9个公共癌症数据集,用于患者集群.
  • 开发了一个XGBoost分类模型来评估不同omics数据类型的重要性.

主要成果:

  • 与现有方法相比,拟议的方法在分离具有不同生存结果 (p < 0.05) 的患者方面表现优越.
  • mRNA被确定为癌症存活的最重要的奥米克特征,其次是DNA甲基化和miRNA.
  • 一个案例研究成功地聚集了亚型,并确定了14个与癌症相关的基因,其中12个 (85.7%) 被文献验证.

结论:

  • 开发的方法有效地识别出统计学和生物学上显著的癌症亚型.
  • 这种方法增强了患者分层和个性化医疗策略.
  • 这项研究提供了一个宝贵的工具,用于使用多omics数据进行癌症分子亚型化.