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Updated: Jun 14, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

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酶催化区域选择性合成4-异质功能化1,5-异位化1,2,3-三醇

Navaneet Kumar1,2, Atul Kumar1,3

  • 1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.

Organic letters
|September 4, 2024
PubMed
概括

新型酶催化反应使得使用2-azido-1,3,5-triazine (ADT) 在水中的1,2,3-triazoles的区域选择性合成成为可能. 这种绿色化学方法提供了广泛的适用性和高产量,用于构建各种三醇化合物.

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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
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α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
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