在向健康的猫给予有的对比剂后,尿液中的清除值
Gabriella Allegrini1, Valerie J Poirier1, Julia G Pezzali2
1Animal Cancer Centre, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Journal of veterinary internal medicine
|September 4, 2024
概括
猫的尿水平在离子对比剂 (ICM) 给药后10天内恢复正常. 这表明,在高甲状腺症的放射性治疗可能适合之前,需要2周的等待期.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 诊断成像诊断成像的使用
- 内分泌学 在内分泌学.
背景情况:
- 来自对比介质的外源可以干扰甲状腺中放射性 (131I) 的吸收.
- 这种干扰对在对比度增强计算机断层扫描 (CT) 后用131I治疗甲状腺功能高的猫有影响.
研究的目的:
- 为了确定尿清除在静脉内 (IV) 输入有的对比剂 (ICM) 后需要多长时间才能恢复到基线.
- 为了在ICM研究和131在甲状腺功能高的猫中进行I治疗之间建立适当的间隔.
主要方法:
- 十只健康的成年雄猫接受了一次IV注射Iopamidol.
- 在ICM给药前和后的不同时间点测量了尿液中的和肌素度.
- 用线性混合效应模型计算和分析尿与肌素比率 (UICR).
主要成果:
- 在ICM后的7天内,尿液中的度显著增加,到第2周恢复到基线.
- 尿清除率在10天内恢复到基线.
- 在ICM后的10天内,尿液中与肌素的比率仍然显著升高.
结论:
- 在健康猫的IVICM注射后大约10天,尿液中清除正常化.
- 对比研究和I治疗之间的2周间隔可能适用于甲状腺功能高的猫.
- 需要进一步的研究来证实这种间隔在甲状腺功能高的猫.
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