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人类遗传的RelB缺陷会损害对感染的先天性和适应性免疫力

Tom Le Voyer1,2,3, Majistor Raj Luxman Maglorius Renkilaraj1,2, Kunihiko Moriya1,2

  • 1Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris 75015, France.

Proceedings of the National Academy of Sciences of the United States of America
|September 4, 2024
PubMed
概括

人类遗传的RelB缺陷破坏了替代NF-κB通路,导致T细胞和B细胞免疫缺陷. 这导致对感染的敏感性增加,以及对I型干扰素的自身抗体增加.

关键词:
通过NF-κB路径.在RelB中存在缺陷.这是自抗体的自抗体.免疫缺陷是一种免疫缺陷.第一种类型的IFN.

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