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基于结构的设计,可溶性人类细胞巨乳病毒糖蛋白B抗原稳定在一种类似于预注射的形状

Madeline R Sponholtz1, Patrick O Byrne1, Alison G Lee1

  • 1Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.

Proceedings of the National Academy of Sciences of the United States of America
|September 4, 2024
PubMed
概括

研究人员使用基于结构的设计稳定了人类细胞巨乳病毒糖蛋白B (gB) 在其预注液状态. 这种稳定提供了开发有效的HCMV疫苗的新策略,并了解对GB的抗体反应.

关键词:
低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.细胞巨型病毒 (cytomegalovirus) 是一种病毒.疹病毒病毒的病毒.疫苗 疫苗 疫苗 疫苗

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