大脑脊髓液流向外围神经延伸,进一步统一神经系统
Alexander P Ligocki1, Augustine V Vinson1, Anthony T Yachnis2
1Program in Stem Cell Biology and Regenerative Medicine, Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
大脑脊髓液 (CSF) 从中枢神经系统 (CNS) 流向周围神经系统 (PNS). 这种CSF循环对于维持整个神经系统的平衡至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 大脑脊髓液 (CSF) 对中枢神经系统 (CNS) 恒温,营养供应和废物清除至关重要.
- 在周围神经系统 (PNS) 中的CSF循环的程度仍然不完全理解.
研究的目的:
- 研究大脑脊髓液 (CSF) 从中枢神经系统 (CNS) 到脑后神经系统 (PNS) 的分布和运输.
- 为了确定CSF在CNS和PNS之间运输的尺寸限制.
主要方法:
- 输注1.9纳米和15纳米金纳米颗粒到中枢神经系统的侧脑室内.
- 使用先进的成像技术追踪PNS内的纳米粒子分布.
- 评估系统管理的纳米颗粒穿越血脑/神经屏障的能力.
主要成果:
- 1.9纳米金纳米颗粒,大小类似于CSF蛋白质,通过根附着区域成功从中枢神经系统传递到脑后神经系统.
- 纳米颗粒分布在PNS周围神经和内神经内,到达远端外围神经轴质.
- 较大的15纳米纳米粒子被限制在中枢神经系统中,形成"染色手",表明尺寸取决于运输限制.
- 静脉注射的1.9纳米纳米颗粒无法穿过血脑或血神经屏障.
结论:
- 大脑脊髓液 (CSF) 在整个周围神经系统 (PNS) 积极循环,而不仅仅是中枢神经系统.
- 这种中枢神经系统 - 脑神经系统中枢神经液通路对理解神经系统恒温有重要意义.
- 这些发现为神经药物输送和针对中枢神经系统和脑神经系统疾病的治疗策略开辟了新的途径.
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