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在上皮癌的诊断中血清类固醇分析:一个前性队列研究

Kai Yu^1,2, Shobana Athimulam³, Jasmine Saini²

¹Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

The Journal of clinical endocrinology and metabolism

|September 4, 2024

概括

血清类固醇分析对诊断上腺皮质癌 (ACC) 有希望. 测量11-脱氧皮质醇,17OH-孕和17OH-孕可以帮助区分ACC与其他上腺质量.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
临床诊断临床诊断临床诊断

背景情况:

建议在未确定上腺瘤的患者诊断上腺皮质癌 (ACC) 时进行尿液类固醇分析.
然而,这种诊断方法在临床实践中并没有得到广泛的应用.

研究的目的:

评估随时可用的血清标记物在诊断ACC时的准确性.
具体来说,这项研究评估了血清中的11-脱氧皮质醇,17OH-孕和17OH-孕的水平.

主要方法:

一项前性单中心队列研究涉及263名上腺质量患者.
使用液体染色体质谱测量量血清类固醇水平.
使用机器学习开发了血清类固醇评分,并通过接收器操作曲线分析验证.

主要成果:

上皮层癌 (ACC) 在16.7%的患者中被诊断出.
与非ACC组相比,在患有ACC的患者中,所有三种测量的血清类固醇都显著升高.
产生的血清类固醇评分显示出在ACC和非ACC之间有很强的区分能力,接收器操作曲线下的面积为0.823.

结论:

血清中11-脱氧皮质醇,17OH-孕和17OH-孕的水平显示出诊断ACC的潜力.
一个验证的血清类固醇评分可能是临床实践中非侵入性ACC诊断的宝贵补充.

关键词:

上腺偶发性瘤上皮层癌 (adrenocortical carcinoma) 是一种上皮层癌.诊断诊断诊断诊断诊断诊断类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型:

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