治疗口癌患者治疗的有效性
Ervin V Lukach1, Viktor Ya Dikhtiaruk1, Oleksandr V Kovtunenko2
1INSTITUTE OF OTOLARYNGOLOGY NAMED AFTER PROF. O.S. KOLOMIYCHENKO OF NAMS OF UKRAINE, KYIV, UKRAINE.
概括
这项关于口腔癌治疗的研究发现,新辅助化疗和放射治疗具有很高的有效性,在大多数患者中实现了显著的瘤回归. 三年生存率为40.8%,五年生存率为27.0%.
科学领域:
- 在瘤学瘤学.
- 癌症治疗方法 癌症治疗方法
- 头部和部癌症 头部和部癌症
背景情况:
- 口腔癌在头部和部瘤学中是一个重大挑战.
- 有效的治疗策略对于改善患者的生存和治疗结果至关重要.
研究的目的:
- 分析被诊断患有口腔癌的患者的治疗结果.
- 为了评估结合新辅助化疗和放射治疗方案的疗效.
主要方法:
- 在2008-2021年期间接受治疗的276名口腔瘤患者队列.
- 新辅助化疗 (帕克利塔塞尔/卡博普拉丁或西斯普拉丁) 随后进行放射治疗 (65 Gy TFD).
- 根据RECIST标准评估治疗反应;统计学分析的生存率.
主要成果:
- 三年生存率为40.8% (95%CI为33.7-47.9),五年生存率为27.0% (95%CI为20.6-33.4).
- 平均存活时间为36个月 (95% CI 35.5-40.2).
- 91.7%的患者在治疗后显示出完全或部分瘤回归.
结论:
- 结合治疗方法在口腔癌中显示出高效率.
- 该疗法导致了显著的瘤回归,短期内没有观察到进展.
- 这项研究强调了这种多式疗法在治疗口腔癌,主要是状细胞癌的潜力.
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