眼睛间差异指标的诊断价值在OCT上用于髓寡基细胞糖蛋白抗体相关的视神经炎
Giulio Volpe1, Neringa Jurkute1, Gabriela Girafa1
1From the Moorfields Eye Hospital NHS Foundation Trust (G.V., N.J., G.G.), London, United Kingdom; Department of Ophthalmology (G.V.), Institute of Clinical Neurosciences of Southern Switzerland (INSI), Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland; Department of Neuro-ophthalmology (N.J.), The National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, The National Hospital for Neurology and Neurosurgery; Institute of Ophthalmology (N.J.), University College London, United Kingdom; Federal University of the State of Rio de Janeiro (UNIRIO) (G.G.), Brazil; Einstein Center for Digital Future Berlin (H.G.Z.); Experimental and Clinical Research Center (ECRC) (H.G.Z., S.M., C.B., A.U.B., F.P., F.C.O.), Max-Delbrueck-Center Berlin & Charité - Universitätsmedizin Berlin; Neuroscience Clinical Research Center (NCRC) (H.G.Z., S.M., C.B., A.U.B., F.P., F.C.O.), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Centre for Advanced Neurological Research (L.P., A.D.C.), Nitte University, Mangalore, India; Department of Medicine (M.R.Y.), David Geffen School of Medicine at UCLA, Los Angeles; Divisions of Molecular Medicine and Infectious Diseases (M.R.Y.), Department of Medicine; Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center (M.R.Y.), Torrance, CA; Departments of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center; Division of Metabolism (T.J.S.), Endocrine and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Pediatrics (L.J.C.), University of Utah; Department of Neurology (F.P., F.C.O.), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; National Hospital for Neurology and Neurosurgery (A.P.), University College London Hospitals NHS Foundation Trust, Moorfields Eye Hospital NHS Foundation Trust and Queen Square Dept. of Neuroinflammation, UCL, Queen Square Institute of Neurology, University College London, United Kingdom; and Neuro-ophthalmology Expert Centre (A.P.), Amsterdam University Medical Center, The Netherlands.
光学连贯性断层扫描 (OCT) 眼间差异 (IED) 度量准确诊断髓寡干细胞糖蛋白抗体相关的视神经炎 (MOG-ON). 斑点质细胞和内状层 (mGCIP) IED指标显示出高灵敏度和特异性,可以将MOG-ON与健康对照区分开来.
科学领域:
- 眼科医生 眼科 眼科
- 神经免疫学 神经免疫学
- 医疗成像医学成像
背景情况:
- 2022年国际视觉神经炎联盟 (ON) 标准包括光学连贯性断层扫描 (OCT).
- 在髓寡干细胞糖蛋白抗体相关的ON (MOG-ON) 中,眼间差异 (IED) 度量的诊断实用性仍然未得到充分研究,尽管它在其他ON病因学中具有既定的价值.
研究的目的:
- 为了验证MOG-ON.基于OCT的IED指标的诊断性能.
- 在识别MOG-ON时,比较不同OCT指标的敏感性和特异性.
主要方法:
- 一项多中心验证研究包括33名MOG-ON患者和33名年龄和性别匹配的健康对照 (HC).
- Spectralis光谱域OCT被用于在ON后六个多月获得结构数据.
- 分析了斑点质细胞和内状层 (mGCIP) 和外皮皮质视网膜神经纤维层 (pRNFL) 的IED截止值,以确定灵敏度,特异性和接收器操作特征.
主要成果:
- 黄斑结节细胞和内状层眼间百分比差异 (mGCIP IEPD) 显示出最高的灵敏度 (92%) 和特异性 (82%).
- 聚合分析显示mGCIP IEAD (88%,82%) 和pRNFL指标 (84%,82%) 的高灵敏度和特异性.
- 与双边ON相比,单边ON病例 (>99%) 的诊断灵敏度显著更高 (61%-78%).
结论:
- 基于OCT的IED指标,特别是mGCIP IEPD,为MOG-ON提供了高诊断准确性.
- 这些发现支持将OCT IED指标纳入MOG-ON的诊断工作组.


