概括
一个基于家庭的炼和激励计划 (HBEP) 正在接受肝移植的接受者中进行测试,以改善生活质量. 这项试验旨在确定HBEP是否能改善移植后的身体和精神健康.
科学领域:
- 移植科学 移植科学
- 临床试验 临床试验
- 康复医学 康复医学 康复医学
背景情况:
- 身体虚弱显著影响肝移植候选人和接受者的死亡率和生活质量 (QoL).
- 目前的证据对这个患者群体量身定制的运动和行为干预措施是有限的.
研究的目的:
- 评估远程监控的家庭运动和动机支持计划 (HBEP) 在改善LT接受者的QOL方面的有效性.
- 评估HBEP对从移植前到LT后24周身体和精神健康的影响.
主要方法:
- 第二期b,开放标签,双中心随机对照试验 (EXALT).
- 成年LT候选人随机分为1:1接受HBEP或标准运动建议小册子.
- 主要结局:在LT后24周,SF-36v2的物理成分得分的差异,根据治疗意图进行分析.
主要成果:
- 样本大小计算需要每组133名患者,占35%.
- 招募正在进行中,截至报告日期,有217/266名患者随机选择.
- 主要结果数据收集将于2026年5月结束.
结论:
- 该EXALT试验将提供关键数据,以改善肝移植接受者的QOL的家庭干预措施的有效性.
- 这些发现将为接受LT治疗的脆弱患者群体的未来康复策略提供信息.
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