总胆红素改变了糖尿病和中风之间的关联:来自NHANES 2011-2016年的横截面研究
Zhang Xia1,2,3, Guozheng Xu1,3, Mingyang Zhao1,3
1Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Journal of neurology, neurosurgery, and psychiatry
|September 4, 2024
概括
增加的总 bilirubin (TBIL) 水平改变了糖尿病和中风之间的联系,特别是在男性中. 较高的TBIL度似乎通过抑制炎症因素来降低与糖尿病相关的中风风险.
科学领域:
- 内分泌学和新陈代谢学
- 心血管研究研究心血管研究
- 生物化学 生物化学
背景情况:
- 总胆红素 (TBIL) 具有已知的抗氧化和抗炎性质.
- 糖尿病,中风和TBIL水平之间的相互作用需要进一步调查.
研究的目的:
- 调查是否增加的总 bilirubin 改变糖尿病和中风之间的关联.
- 确定影响这种修改的具体门和人口因素.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 数据 (2011-2016).
- 采用多变量逻辑回归和约翰逊-尼曼分析来评估TBIL对糖尿病-中风关系的修饰作用.
- 进行调解分析以评估TBIL对炎症标志物的影响.
主要成果:
- 糖尿病与TBIL<10.3μmol/L (OR=2.19) 的中风风险增加有关,但TBIL≥10.3μmol/L (OR=1.27) 的风险并非如此.
- 这种修改效应显著 (P=0.03) 在男性中明显 (P=0.02).
- 升高的TBIL (≥10.3μmol/L) 抑制了C反应蛋白和全身免疫炎症指数的介导作用.
结论:
- 增加的总 bilirubin 显著改变糖尿病和中风之间的关联.
- 这种修改是通过抑制炎症因子来调节的,在男性中观察到显著的效果.
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