多发性硬化症的长期残疾轨迹:对AusLong队列的基于小组的轨迹分析
Amin Zarghami1, Mohammad Akhtar Hussain2,3, Ingrid van der Mei1
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Journal of neurology, neurosurgery, and psychiatry
|September 4, 2024
概括
早期临床因素,如年龄和复发预测多发性硬化症 (MS) 的残疾进展. 识别这些轨迹有助于在复发性多发性硬化症患者的早期干预.
科学领域:
- 神经学 神经学
- 临床神经科学 临床神经科学
- 流行病学 流行病学
背景情况:
- 对于渐进的多发性硬化症 (MS) 已知残疾进展的异质性.
- 关于复发性多发性硬化症中残疾累积的证据有限.
- 了解早期的MS轨迹对于预后至关重要.
研究的目的:
- 在中枢神经系统脱髓化 (FCD) 的首次临床诊断后10年内,调查复发性MS中残疾进展异质性.
- 确定影响这些残疾轨迹的因素.
- 为早期干预策略提供信息.
主要方法:
- 用于263名参与者的扩展残疾状况表 (EDSS) 数据的基于组的轨迹模型.
- 未来十年的前性队列评估.
- 排除了复发后3个月内的EDSS数据,以专注于持续的残疾.
主要成果:
- 确定了三个残疾轨迹:没有/最小的进展,中度和严重的进展.
- 年龄较大,复发较早,并携带疾病预测了更糟糕的发展轨迹.
- 基线MRI和初始症状部位对长期结果没有影响.
结论:
- 早期临床特征可以识别患有更快MS残疾进展风险的个体.
- 这些发现对及时的治疗干预和治疗升级有影响.
- 复发性多发性硬化症残疾的预后标志物可以在疾病的早期确定.
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