在日本,在日本的狗中,尿液中甲基氨酸与肌氨酸比率的参考间隔
Noriyuki Nagata1,2, Yoshinori Ikenaka3,4,5,6, Hiryu Sawamura2
1Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
The Journal of veterinary medical science
|September 4, 2024
概括
在健康的狗中,确定尿中诺米他内与肌素的比率 (uNMN/Cr) 和尿中甲基他内与肌素的比率 (uMN/Cr) 的参考间隔对于诊断染细胞瘤 (PCC) 至关重要. 采集尿液的方法对这些诊断比率有很大影响.
科学领域:
- 兽医诊断 兽医诊断 兽医诊断 兽医诊断
- 临床生物化学 临床生物化学
- 内分泌学 在内分泌学.
背景情况:
- 染细胞瘤 (PCC) 是一种上腺瘤,需要精确的诊断方法.
- 尿中诺美甲尼与肌素的比率 (uNMN/Cr) 和尿中甲尼与肌素的比率 (uMN/Cr) 是对犬类PCC诊断的关键生物标志物.
- 建立特定物种和特定种群的参考间隔对于可靠的诊断解释至关重要.
研究的目的:
- 在健康的日本犬中确定UNMN/Cr和UMN/Cr的参考间隔.
- 评估尿液收集方法 (医院与家庭) 对这些尿液比率的影响.
- 在兽医实践中提供支持准确PCC诊断的数据.
主要方法:
- 分析尿中诺米他内和米他内的度.
- 用于计算比率的肌素测量 (uNMN/Cr和 uMN/Cr).
- 统计分析以确定参考间隔,并比较健康和非PCC狗的采集方法.
主要成果:
- 对于nMN/Cr和umN/Cr参考区间的确定的上限分别为124.4nmol/mmol和121.1nmol/mmol.
- 当尿液在医院环境中收集时,与在家收集相比,观察到UNMN/Cr和UMN/Cr值显著更高.
- 确定了上限的置信区间 (90% CI 107.7-137.0对于nMN/Cr;90% CI 102.8-145.1对于nMN/Cr).
结论:
- 该研究提供了日本犬类UNMN/Cr和UMN/Cr的重要参考间隔.
- 尿液采集方法是影响诊断测试结果的关键变量.
- 建议考虑采集方法,以便在犬类PCC诊断中准确解释UNMN/Cr和UMN/Cr.
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