多发性硬化症中的行为障碍:综合性综述
1Institute of Clinical Neurobiology, Alberichgasse 5/13, Vienna, A-1150, Austria. kurt.jellinger@univie.ac.at.
Journal of neural transmission (Vienna, Austria : 1996)
|September 4, 2024
概括
多发性硬化症 (MS) 的行为变化很常见,影响30-80%的患者,影响日常生活. 早期识别和有针对性的干预措施对于管理多发性硬化和改善患者结果至关重要.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统的自身免疫性疾病,导致炎症,脱髓化和神经退行.
- 行为变化是MS中常见的神经精神病症状,早期出现并随着疾病的进展而恶化.
- 这些变化,包括执行功能障碍和情绪障碍,在很大程度上导致MS相关的残疾.
研究的目的:
- 审查当前关于MS行为变化的流行病学,临床,神经成像和病原遗传方面的证据.
- 为了确定在MS的行为症状潜在的早期诊断标志物.
- 探索新的治疗目标和策略,以管理MS的行为障碍.
主要方法:
- 在PubMed,谷歌学者和科克兰图书馆的系统文献综述.
- 分析与MS行为变化相关的流行病学,临床,神经成像和病原遗传数据.
- 检查了脱髓化动物模型和人类神经成像研究的发现.
主要成果:
- 行为变化影响了多发性硬化症患者的30-80%,并且通常与认知缺陷有关,而不是运动障碍.
- 神经成像揭示了前额叶皮层缩以及MS中前额-状-thalamic和前额-parietal网络的破坏.
- 动物模型显示脱髓化和人类白质/神经炎症异常之间存在相似之处.
结论:
- 行为症状是MS的重要和常见特征,需要进一步研究其特定的病理机制.
- 早期识别行为变化对于全面的MS管理至关重要.
- 包括社会,心理,行为和基于炼的方法在内的干预措施显示出改善结果的希望.
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