改进计算病理学的注释过程:在消费者和医疗级设备上使用手动和半自动方法的试点研究
Giorgio Cazzaniga1, Fabio Del Carro1, Albino Eccher2
1Department of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo Dei Tintori, University of Milano-Bicocca, Via Pergolesi, 33, 20900, Monza, Italy.
Journal of imaging informatics in medicine
|September 4, 2024
概括
使用分段任何模型 (SAM) 的半自动注释显著加快了病理图像分析,并与手动方法相比提高了可重现性. 这种人工智能辅助的方法增强了开发可靠的人工智能算法在数字病理学的基础真相.
科学领域:
- 数字病理学数字病理学
- 人工智能在医学中的应用
- 计算病理学计算病理学
背景情况:
- 在病理学中开发可靠的人工智能 (AI) 算法需要从整个幻灯片图像 (WSI) 注释中获得准确的基准真实数据.
- 手动注释WSI是一个耗时且依赖于操作者的过程,阻碍了高效的AI开发.
- 探索简化注释方法对于在病理学中推进AI至关重要.
研究的目的:
- 在整个幻灯片图像中比较脏组织的不同注释方法的效率,可重现性和精度.
- 为了评估半自动化方法 (Segment Anything Model - SAM) 与手动方法 (鼠标和触摸板) 的性能.
- 评估注释工具和操作员可变性对人工智能开发基础真相生成的影响.
主要方法:
- 两位病理学家使用半自动 (SAM) 和手动 (鼠标,触摸板) 工具对脏组织部位 (管道,淋巴细胞,动脉) 进行了注释.
- 关键指标包括工作时间,可重复性 (重叠率) 和精度 (精度等级).
- 还分析了不同显示器对鼠标注释性能的影响.
主要成果:
- 半自动SAM方法显著更快 (13.6分钟) 和显示较小的观察者之间的变化 (2%的差异),比老鼠 (29.9分钟,24%的差异) 和触摸板 (47.5分钟,45%的差异).
- SAM在管状 (1.0) 和质 (0.99) 中实现了最高的可重复性,而鼠标和触摸板显示的值略低.
- 操作人员之间没有发现显著的精度差异 (p=0.59),但非医疗监视器增加了6.1%的注释时间.
结论:
- 半自动化和人工智能辅助的注释方法,如SAM,可以大大加快数字病理学的基础真相生成过程.
- 这些先进的方法提供了提高效率和可重复性,这对于开发强大的AI工具至关重要.
- 优化注释工作流程是提高AI在病理诊断中的可靠性和可扩展性的关键.
相关概念视频
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Equipments Used To Measure Blood Pressure
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...


