古代病毒和人类肠道的主导甲原体之间的稳定共存
Diana P Baquero1, Sofia Medvedeva2, Camille Martin-Gallausiaux2
1Institut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, Paris, France.
Nature communications
|September 4, 2024
概括
科学家们描述了人类肠道古老病毒 (MSTV1) 感染Metanobrevibacter smithii. 这项研究揭示了MSTV1如何与宿主保持持久,低级别的共存,类似于菌体.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 肠道微生物组研究研究
背景情况:
- 人体肠道病毒组包括感染古生物的病毒,但由于孤立的数量有限,它们的作用尚不清楚.
- Methanobrevibacter smithii是人类肠道中占主导地位的甲原体,使其病毒成为研究的关键目标.
研究的目的:
- 为了描述一个温带古老的病毒,MSTV1,感染 Methanobrevibacter smithii.
- 阐明病毒与宿主相互作用和在肠道环境中的共存机制.
主要方法:
- 低温电子断层扫描可视化细胞内病毒组合.
- 在体外和体内 (老鼠殖民模式) 实验中评估病毒诱导频率.
- 转录组分析以调查监管机制.
主要成果:
- MSTV1作为前病毒集成到宿主染色体中,并偶尔被诱导,导致低频病毒释放.
- 宿主群体中很小的一小部分在体外和小鼠模型中都能积极产生病毒.
- 转录基因数据表明,一个调节性溶解生成-溶解开关涉及病毒蛋白相互作用.
结论:
- 这项研究描述了MSTV1,一种来自人类肠道的古老病毒,以及它与Methanobrevibacter smithii的相互作用.
- MSTV1与宿主建立了稳定的共存,反映了细菌菌体中看到的策略.
- 这些发现增强了对古老病毒宿主动态和更广泛的肠道病毒组合的理解.
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