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角膜的生物力学特性和潜在的影响因素在不同程度的近视

Yunxiao Sun¹, Yiqin Guo¹, Ruiqi Pang¹

¹Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.

Scientific reports

|September 4, 2024

概括

高近视与角膜硬度降低有关,独立于眼内压力和角膜厚度. 这些角膜生物机械变化可以预测硬质的强度,有助于近视管理.

科学领域:

眼科医生眼科眼科
生物机械工程生物机械工程
视觉科学科学视觉科学

背景情况:

角质生物力学在保持眼睛的完整性方面发挥着至关重要的作用.
近视,特别是高近视,与眼睛的结构变化有关.
了解近视如何影响角膜生物力学对于预测疾病进展和管理并发症至关重要.

研究的目的:

为了比较不同近视严重程度的Corvis ST测量的角膜生物力学参数.
调查影响近视患者角膜生物机械性能的因素.
评估角膜生物力学与折射误差 (球体等价,SE) 和轴长 (AL) 之间的关系.

主要方法:

对224名健康近视患者的304只眼睛进行了前性横截面研究.
根据SE和AL,分类为非近视 (NM),轻度至中度近视 (MM) 和高近视 (HM) 组.
使用线性混合效应模型和多重线性回归分析十个角膜生物力学参数,调整生物力学纠正眼内压力 (bIOP) 和中角膜厚度 (CCT).

主要成果:

与非近视眼相比,高近视 (HM) 的眼睛表现出较短的最高腔时间 (HC-time),更大的峰值距离 (PD),更大的偏移幅度 (DA-Max),更小的整眼运动 (WEM-Max) 和降低的刚性参数 (SP-A1),在对bIOP和CCT进行调整后.
HC-时间,PD,DA-Max,WEM-Max和SP-A1与轴长 (AL) 有显著的相关性.
科维斯生物力学指数显示与球体等价值 (SE) 有显著的关系.

结论:

越来越严重的近视与角膜硬度的逐渐减少有关,独立于bIOP和CCT.
来自Corvis ST测量的角膜生物力学参数可以作为高近视时膜机械强度的预测指标.
这些发现对近视治疗具有潜在的临床价值.

关键词:

轴长度轴长度轴长度角膜的生物机械性质科维斯STST 科维斯ST 球体相当的球体等价物.短视的不同程度.

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