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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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针对中枢神经系统损伤的工程T细胞疗法

Wenqing Gao1,2, Min Woo Kim3,4,5,6, Taitea Dykstra3,4

  • 1Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, School of Medicine, St. Louis, MO, USA. gaow@wustl.edu.

Nature
|September 4, 2024
PubMed
概括

研究人员发现脊髓损伤中的T细胞向自我蛋白质. 工程T细胞显示神经保护,为中枢神经系统 (CNS) 损伤治疗提供了新的途径.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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