在粉酶位点的重复进化和选择形状结构多样性
Davide Bolognini1, Alma Halgren2, Runyang Nicolas Lou2
1Human Technopole, Milan, Italy.
Nature
|September 4, 2024
概括
农业革命导致了人类更多的粉酶基因拷贝,有助于粉的消化. 这些基因复制是积极选择所驱动的, 在过去的12000年里, 它们的频率迅速增加.
科学领域:
- 人类进化遗传学
- 基因组学
- 考古学科学
背景情况:
- 转向农业大大改变了人类的饮食, 增加了对粉的依赖.
- 粉酶基因对粉消化至关重要,其拷贝数量与饮食习惯有关.
- 关于氨酶基因拷贝数的最近选择的先前证据是有限的.
研究的目的:
- 研究粉酶位点的结构变异的多样性和进化史.
- 了解农业革命对人类氨基酶基因拷贝数的影响.
- 确定对糖酶基因结构变异的选择证据.
主要方法:
- 分析了94个长时间读取的类型解析组件和约5,600个短时间读取的人类基因组数据 (当代和古代).
- 以泛基因组为基础的方法,在多样化的人类群体中推断结构性单元型.
- 通过利用533个古人类基因组, 追踪12,000年间的单个基因组频率变化.
主要成果:
- 确定了28种不同的粉酶基因结构结构,具有类似结构的反复演变.
- 与非农业群体相比,农业群体的氨酶基因复制数量更高.
- 在过去的12,000年里,含有复制的平分类型与增加的基因拷贝的频率迅速增加.
结论:
- 自农业革命以来,人类的酶基因拷贝数量和结构发生了显著的适应.
- 氨基酶位点的结构变化显示出积极选择的强烈信号,以应对饮食变化.
- 这项研究强调了结构变化的作用,
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